handling node.js http requests with intervals

i am creating a node.js application that has multiple integrations with different systems , i am worried about the following :

1 - i have to request all integrations every 1 second , whats the best way to handle http requests with intervals ?

2 - should i keep this type of integrations on the same web application or should i have something live workers , whats the best way to handle that considering that am using expressJS.

so its not like a normal api , i have something sending requests all the time , any recommendations or best practices ?

Cheers,

via Hasan Al-Natour