node express vhosts VS multiple node applications on NGINX server

Is is possible to have an answer "to have and idea" with this info? :

In terms of performance ( basically speed )

QUESTION 1

1: what would be best to set on a nginx server :

Considering domains:

• http://example1.com
• https://example2.com
• https://example3.com
• https://example4.com
• https://mailserver.example3.com
• https://mailserver.example4.com2
• https://sub1.example2.com
• https://sub2.example2.com
• https://sub3.example2.com

All domains and subdomains might let the user connect with one Authentication using Passport on all domains/subdomains

A) Nginx vhosts for A (one) node app with multiple express vhosts for each domain. (i'm aware in this case I would have to restart all domains when I have to update one site)

B) Nginx vhosts for each node app for each domain.

QUESTION 2

2) Would it change much this performance if also want to use this server for , lets say, two additional ssl api with php ?

Thanks in advance.

via MikRut